LymphedemaV1, Main, Exploration, bibRecord, 00B584

Brugia malayi in Mastomys coucha : establishment in immunosuppressed animals

Identifieur interne : 00B584 ( Main/Exploration ); précédent : 00B583; suivant : 00B585

Brugia malayi in Mastomys coucha : establishment in immunosuppressed animals

Auteurs : K. Tyagi [Inde] ; P. K Murthy [Inde] ; R. K Chatterjee [Inde]

Source :

Acta Tropica [ 0001-706X ] ; 1998.

RBID : ISTEX:A96ACD62D8EE1BA4B444032A1990B41B75472545

English descriptors

KwdEn :
- Brugia malayi, Cortisone, Immunosuppressed, Mastomys coucha.

Abstract

Investigations on various aspects of human filariasis using target filarial parasite, Brugia malayi is jeopardised to a great extent due to its prolonged incubation period and poor harvest from the existing experimental animal models. To obviate these difficulties it was contemplated to establish B. malayi infection in immunosuppressed Mastomyscoucha. Cortisone, a well known immunosuppressant, was used at 10 mg/kg dose level subcutaneously in two courses each of 5 days duration. The first course was administered 1 week before and the second, a week after infective exposure. Mastomys were exposed either with 100 or 200 infective larvae (L3) each. Untreated age-matched animals were also exposed simultaneously. The minimum prepatent period was observed to be 90.7 days in immunosuppressed animals exposed to 200 L3. The course of microfilaraemia in immunosuppressed and control animals was identical upto 180 days of observation period. However, the adult worm recovery from the former group of Mastomys was higher. It is surmised that exposure with B. malayi L3 in immunosuppressed Mastomys would be of great advantage in getting larger harvests of adult worms of B. malayi.

Url:

DOI: 10.1016/S0001-706X(98)00015-1

Affiliations:

Inde

Le document en format XML

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<front><div type="abstract" xml:lang="en">Investigations on various aspects of human filariasis using target filarial parasite, Brugia malayi is jeopardised to a great extent due to its prolonged incubation period and poor harvest from the existing experimental animal models. To obviate these difficulties it was contemplated to establish B. malayi infection in immunosuppressed Mastomyscoucha. Cortisone, a well known immunosuppressant, was used at 10 mg/kg dose level subcutaneously in two courses each of 5 days duration. The first course was administered 1 week before and the second, a week after infective exposure. Mastomys were exposed either with 100 or 200 infective larvae (L3) each. Untreated age-matched animals were also exposed simultaneously. The minimum prepatent period was observed to be 90.7 days in immunosuppressed animals exposed to 200 L3. The course of microfilaraemia in immunosuppressed and control animals was identical upto 180 days of observation period. However, the adult worm recovery from the former group of Mastomys was higher. It is surmised that exposure with B. malayi L3 in immunosuppressed Mastomys would be of great advantage in getting larger harvests of adult worms of B. malayi.</div>
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Brugia malayi in Mastomys coucha : establishment in immunosuppressed animals

Brugia malayi in Mastomys coucha : establishment in immunosuppressed animals

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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